SYNTHESIS OF PYRRYL ARYL SULFONES TARGETED AT THE HIV-1 REVERSE-TRANSCRIPTASE

Authors
ARTICO M SILVESTRI R STEFANCICH G MASSA S SCINTU F PAGNOZZI E MASU D PINNA E TINTI E LACOLLA P
Citation
M. Artico et al., SYNTHESIS OF PYRRYL ARYL SULFONES TARGETED AT THE HIV-1 REVERSE-TRANSCRIPTASE, Archiv der pharmazie, 328(3), 1995, pp. 223-229
Citations number
19
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
328
Issue
3
Year of publication
1995
Pages
223 - 229
Database
ISI
SICI code
0365-6233(1995)328:3<223:SOPAST>2.0.ZU;2-5
Abstract
Various aryl 1-pyrryl sulfones were synthesized and tested as inhibito rs of HIV-1, 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the a ryl pyrryl sulfone series. The in vitro anti-HIV-1 activity and cytoto xicity of 41 compounds is reported. Some structure-activity relationsh ips are discussed also in comparison with the known NPPS (2-nitorpheny l phenyl sulfone).