POLYCYCLIC AZINES .15. SYNTHESIS OF HETER OXYCLIC IMMUNOMODULATORS .2. APTOALKYLTHIENO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONES - SYNTHESIS AND TEST FOR IMMUNOSTIMULATING ACTIVITY
M. Gutschow et al., POLYCYCLIC AZINES .15. SYNTHESIS OF HETER OXYCLIC IMMUNOMODULATORS .2. APTOALKYLTHIENO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONES - SYNTHESIS AND TEST FOR IMMUNOSTIMULATING ACTIVITY, Archiv der pharmazie, 328(3), 1995, pp. 231-234
A series of aptoalkylthieno[2,3-d]pyrimidine-2,4(1H,3H)-diones 3 was p
repared and their immune-stimulating activity was examined. The title
compounds were obtained conveniently bp hydrolytic ring cleavage of fu
sed thiazolo- or 1,3-thiazino-thienopyrimidines 1 under alkaline or ac
idic reaction conditions. The ms fragmentation of the thieno[2,3-d]pyr
imidine-2,4-diones 3 is discussed. In the delayed type hypersensitivit
y (DTH) test some compounds 3 showed immune-stimulating activities in
the range of isoprinosine.