P. Gmeiner et al., SYNTHESIS OF (S)-3,4-DIAMINOBUTANENITRILES AS PRECURSORS FOR 3-AMINO-GABA DERIVATIVES, Archiv der pharmazie, 328(3), 1995, pp. 265-268
Starting from natural asparagine (1) a synthesis of the protected (S)-
3,4-diaminobutanenitriles 5 and 8a-c via the beta-homoserine derivativ
e 2 is described. The amino function in position 4 was introduced by M
itsunobu-coupling or by reductive amination when a strange deformylati
on of the amino aldehyde 7 was observed as a side reaction. The Mitsun
obu-product 5 was converted into the dibenzylamine substituted GABA 6b
which was investigated for its affinity at the GABA-A receptor.