ANTIOXIDANT PROPERTIES OF PHENYL STYRYL KETONES

Phenolic and non phenolic derivatives of phenyl styryl ketones were sy nthesized and evaluated as in vitro inhibitors of iron and cumene hydr operoxide dependent lipid peroxidation in rat brain homogenates. The c ompounds were also tested for antioxidant activity in phosphatidylchol ine liposomes. Phenyl 3,5-di-tert-butyl-4-hydroxystyryl ketone was fou nd to be the most potent inhibitor of peroxidation among all the compo unds tested. It was found to be more active than vitamin E. It also re duced the stable free radical 1,1-diphenyl-2-picrylhydrazyl to an appr eciable extent.