SEVERE OVARIAN HYPERSTIMULATION SYNDROME (OHSS) AND ICTERUS

Severe ovarian hyperstimulation syndrome (OHSS) leads to changes in la boratory analyte concentrations, Whereas elevated aminotransferase act ivity is often observed, a cholestatic course with hyperbilirubinaemia and icterus seldom occurs, In this report, the case of a 33 year old patient with polycystic ovary syndrome (PCOS) is described who, after stimulation with human menopausal gonadotrophin (HMG), developed sever e OHSS with haemoconcentration, ascites, hydrothorax, elevated aminotr ansferases, hyperbilirubinaemia and icterus, The patient did not becom e pregnant and the OHSS regressed, together with the normalization of laboratory and clinical parameters and disappearance of the icterus, D uring the course of an OHSS cholestasis with icterus may occur, which could be explained by a reactive cholestatic hepatosis as a reaction t o the hormonal changes induced by the stimulation therapy.