NUCLEIC-ACID COMPARTMENTALIZATION WITHIN THE CELL-NUCLEUS BY IN-SITU TRANSFERASE-IMMUNOGOLD TECHNIQUES

In the present review, we report on recent results obtained by in situ transferase-immunogold techniques as to the ultrastructural distribut ion of DNA and RNA within the cell nucleus. Special emphasis is placed on the various nucleolar components and the various enigmatic structu res of the extranucleolar region: interchromatin granules, coiled bodi es, and simple nuclear bodies. These data are discussed in the light o f our current understanding of the functional organization of the cell nucleus. (C) 1995 Wiley-Liss, Inc.