A NEW GERMACRANOLIDE FROM TANACETUM-DENSUM SSP SIVASICUM (COMPOSITAE)

Members of the Tanacetum genus are important medicinal plants found th roughout the world which have been used in traditional medicines throu ghout the world.(1) In Turkey, 44 different species of Tanacetum are k nown, at least 15 of which are endemic.(2) One such endemic species, T . densum, is further classified into four subspecies: subsp. sivasicum , subsp, laxum, subsp, amani, and subsp. eginense. As with other membe rs of the Compositae family, T. densum has been shown to produce a var iety of sesquiterpenes, and investigations into subsp. sivasicum have previously yielded eudesmanolides, germacranolides, guaianolides, and farnesol derivatives.(3,4) In this paper we report a new germacranolid e 1 from T. densum subsp. sivasicum