Members of the Tanacetum genus are important medicinal plants found th
roughout the world which have been used in traditional medicines throu
ghout the world.(1) In Turkey, 44 different species of Tanacetum are k
nown, at least 15 of which are endemic.(2) One such endemic species, T
. densum, is further classified into four subspecies: subsp. sivasicum
, subsp, laxum, subsp, amani, and subsp. eginense. As with other membe
rs of the Compositae family, T. densum has been shown to produce a var
iety of sesquiterpenes, and investigations into subsp. sivasicum have
previously yielded eudesmanolides, germacranolides, guaianolides, and
farnesol derivatives.(3,4) In this paper we report a new germacranolid
e 1 from T. densum subsp. sivasicum