STEREOSELECTIVE TOTAL SYNTHESIS OF (2R,2'S,3Z)-1-0-(2-METHOXYHEXADECENYL)GLYCEROL AND (2R,2'S)-1-(2'-METHOXYHEXADECYL)GLYCEROL-POTENTIAL ANTITUMOR COMPOUNDS FROM SHARK LIVER OIL

A simple and high yielding route for the stereoselective synthesis of alkyl glycerol ethers namely (2R,2'S,3Z)-1-O-(2-methoxyhexadecenyl)gly cerol 1 and (2R,2'S)-1-(2'-methoxyhexadecyl) glycerol 2, isolated form Shark liver oil is reported. The key reaction involves the Wittig ole fination of the chiral aldehyde 12 with the ylide generated from tride cyl triphenyl phosphonium bromide results in the formation of compound 13, a precursor for the title compounds 1 and 2.