T. Kitsugi et al., INFLUENCE OF DISODIUM (1-HYDROXYTHYLIDENE) DIPHOSPHONATE ON BONE INGROWTH INTO POROUS, TITANIUM FIBER-MESH IMPLANTS, The Journal of arthroplasty, 10(2), 1995, pp. 245-253
The influence of disodium (1-hydroxythylidene) diphosphonate on the bo
nding between bone and porous, titanium fiber-mesh implants was studie
d. Rectangular, porous, titanium fiber-mesh implants (15 x 10 x 2.4 mm
) were implanted into the tibial bone of mature male rabbits. The rabb
its were divided into six groups. Disodium diphosphonate was administe
red daily by subcutaneous injection to groups 1-5. Groups 1-4 received
doses of 5.0, 2.5, 1.0, and 0.1 mg per kilogram of body weight per da
y for 8 weeks, respectively. Group 5 received a dose of 5 mg per kilog
ram of body weight per day for 4 weeks. Group 6 (control group) was gi
ven saline injections. At 8 weeks after implantation, the rabbits were
killed. The tibiae containing the implants were dissected out and sub
jected to detachment tests. The failure load, when an implant became d
etached from the bone or when the bone itself broke, was measured. The
interface of the bone and implant was investigated by Giemsa surface
staining and contact microradiography. Giemsa surface staining and con
tact microradiography showed that porous implant bonding to bone tissu
e was inhibited by a high dose of disodium diphosphonate in groups 1,
2, and 5. Soft tissue was observed at the interface. Ln groups 3, 4, a
nd 6, bone tissue ingrowth was observed at the interface between the p
orous implant and bone tissue. Growth of bone into the porous fiber-me
sh implant of a cementless prosthesis is possible if a low dose of dip
hosphonate below 1.0 mg per kilogram of body weight is given subcutane
ously.