BIOSYNTHESIS OF TETRONASIN .4. PREPARATION OF DEUTERIUM-LABELED C19-C26, C17-C26, C-11-C26 AND C3-C26 POLYKETIDE FRAGMENTS AS PUTATIVE BIOSYNTHETIC PRECURSORS OF THE IONOPHORE ANTIBIOTIC TETRONASIN (ICI-139603)

Authors
BOONS GJ CLASE JA LENNON IC LEY SV STAUNTON J
Citation
Gj. Boons et al., BIOSYNTHESIS OF TETRONASIN .4. PREPARATION OF DEUTERIUM-LABELED C19-C26, C17-C26, C-11-C26 AND C3-C26 POLYKETIDE FRAGMENTS AS PUTATIVE BIOSYNTHETIC PRECURSORS OF THE IONOPHORE ANTIBIOTIC TETRONASIN (ICI-139603), Tetrahedron, 51(18), 1995, pp. 5417-5446
Citations number
69
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
18
Year of publication
1995
Pages
5417 - 5446
Database
ISI
SICI code
0040-4020(1995)51:18<5417:BOT.PO>2.0.ZU;2-9
Abstract
Six deuterium labelled N-acylcysteamine polyketide derivatives (3)-(8) have been prepared as putative precursors for incorporation in studie s of the biosynthesis of the ionophore antibiotic tetronasin (1). The route to these compounds was designed to flexible and to maximise the use of common synthetic fragments.