OZONOLYSIS OF 2-(1,4-CYCLOHEXADIENYL)GLYCINE

Derivatives of 2-(1,4-cyclohexadienyl)glycine were subjected to total ozonolysis. The free esters as well as the N-protected esters tend to cyclize to yield 2-carbethoxy-3-hydroxy pyrrole derivatives. By treatm ent of the ozonolysis mixture with hydroxylamine or phenylhydrazine he terocyclic derivatives of glycine were obtained. The structure and for mation of pyrazolyl and isoxazolyl glycine derivatives is discussed. T he structure of N-acetyl-2-(1-phenylpyrazol-3-yl)glycine ethyl ester b y X-ray single crystal analysis is reported.