Ms. Luer et al., REGIONAL CEREBRAL OXYGEN-SATURATION DURING INTRAARTERIAL PAPAVERINE THERAPY FOR VASOSPASM - CASE-REPORT, Neurosurgery, 36(5), 1995, pp. 1033-1036
CEREBRAL ARTERIAL VASOSPASM continues to be a major secondary medical
complication of aneurysmal subarachnoid hemorrhage. Despite hypervolem
ic hemodilution, arterial hypertension, and pharmacological therapy, m
orbidity and mortality due to vasospasm remain high. The authors discu
ss a patient with vasospasm who did not respond to traditional medical
therapy and who underwent intra-arterial papaverine infusions while b
eing monitored with transcranial cerebral oximetry. Oximetry during th
e procedure revealed significant improvements in brain regional satura
tion of oxygen, with the relief of vasospasm that correlated with clin
ical improvements in the patient's neurological status. Transcranial c
erebral oximetry was used to monitor regional oxygen saturation throug
hout the angiographic and interventional procedures, providing continu
ous, real-time, clinically relevant information about the effects of v
asospasm and its treatment.