JUST ADD WATER - THE EFFECT OF WATER ON THE SPECIFICITY OF PROTEIN-LIGAND BINDING-SITES AND ITS POTENTIAL APPLICATION TO DRUG DESIGN

Authors
LADBURY JE
Citation
Je. Ladbury, JUST ADD WATER - THE EFFECT OF WATER ON THE SPECIFICITY OF PROTEIN-LIGAND BINDING-SITES AND ITS POTENTIAL APPLICATION TO DRUG DESIGN, Chemistry & biology, 3(12), 1996, pp. 973-980
Citations number
39
Categorie Soggetti
Biology
Journal title
Chemistry & biology → ACNP
ISSN journal
10745521
Volume
3
Issue
12
Year of publication
1996
Pages
973 - 980
Database
ISI
SICI code
1074-5521(1996)3:12<973:JAW-TE>2.0.ZU;2-O
Abstract
Recent data have highlighted the enigmatic role that water plays in bi omolecular complexes. Water at the interface of a complex can increase the promiscuity of an interaction, yet it can also provide increased specificity and affinity. The ability to engineer water-binding sites into the interface between a drug and its target might prove useful in drug design. (C) Current Biology Ltd.