Endogenous substances resulting from interactions between alcohol and
possibly opioid metabolites and neurotransmitters (dopamine, indolamin
es) could be mediators of the pathochemical process towards dependence
. Beta-carbolines (harman/norharman) are increased in alcoholics and -
according to the presented results - in heroin addicts. Psychopatholo
gical disorders such as anxiety or depression do not seem to influence
the level of beta-carbolines.