SENSITIZATION TO GANODERMA-LUCIDUM IN PATIENTS WITH RESPIRATORY ALLERGY IN INDIA

Although human sensitization to basidiomycete Ganoderma has been repor ted in New Zealand, North America and Europe, hypersensitivity due to this fungi is not known in India, in spite of its prevalence in the at mosphere. We have studied the atmospheric concentration of Ganoderma i n different localities within Delhi and the sensitization level to thi s fungi amongst the Indian population. Aerobiological sampling, using a Burkard personal slide sampler, was carried out in Delhi for 2 conse cutive years (October 1989-September 1991). The sampler was operated a t 10 day regular intervals for 10 min to trap the spores. The peak sea son for Ganoderma is recorded from July to September with highest aver age monthly catch of 336 spores/m(3) in September 1991 from south Delh i. Antigenic extracts were prepared from both, the spores and whole bo dy of Ganoderma lucidum. The results of intradermal skin tests conduct ed on 172 patients revealed that 28.48% and 17.44% of patients showed marked skin reactivity to spore and whole body extracts, respectively. A significant correlation (1 = 0.963, P < 0.01) was found between int radermal and skin-prick tests. More than 80% of the intradermal test p ositive patients had significantly (P < 0.01) elevated IgE antibodies to the fungi in question. Thus, sensitization to Ganoderma lucidum has been reported for the first time in the atopic population of India.