POLARIZATION OF TH-CELL RESPONSES - A PHYLOGENETIC CONSEQUENCE OF NONSPECIFIC IMMUNE DEFENSE

Authors
GARSIDE P MOWAT AM
Citation
P. Garside et Am. Mowat, POLARIZATION OF TH-CELL RESPONSES - A PHYLOGENETIC CONSEQUENCE OF NONSPECIFIC IMMUNE DEFENSE, Immunology today, 16(5), 1995, pp. 220-223
Citations number
26
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
16
Issue
5
Year of publication
1995
Pages
220 - 223
Database
ISI
SICI code
0167-5699(1995)16:5<220:POTR-A>2.0.ZU;2-1
Abstract
CD4(+) T helper (Th)-cell responses are polarized into Th1 and Th2 typ es. Here, Paul Garside and Allan McI. Mowat propose that this is an ev olutionary consequence of the relationship between specific adaptive i mmunity, individual components of the nonspecific inflammatory respons e and different types of infection. This concept has important implica tions both for understanding protective immunity and for vaccine desig n and delivery.