ACUTE ORAL TOXICITY OF THE HERBICIDE BUREX EKO IN PHEASANTS

The aim of this study was to determine the acute LD(50), clinical symp toms and pathological changes of acute BUREX EKO intoxication in pheas ants according to OECD No 205. Medium lethal dose (LD(50)) of BUREX EK O in pheasant is 3.84 ml/kg body weight with the upper level of reliab ility 4.50 ml and lower level of reliability 3.27 ml/kg body weight. A s far as the calculation to the effective substance is concerned it is 1 077 mg of chloridazone per kg body weight with the interval of reli ability from 919 to 1 263 mg/kg body weight. Calculated the effective substance of chloridazone (3.84 ml is LD(50) of BUREX EKO which contai ns 1 077 mg of chloridazone) BUREX EKO can be classified as the modera tely toxic substance to pheasants. There were following clinical sympt oms of the BUREX EKO intoxication in pheasants: apathy, drowsiness, in capability to move, ruffled feathers, slight diarrhoea, strenuous resp iration, tonico-clonical cramps before death, decease with the head ex pressively bent rearwards. There was a relatively fast beginning of ri gor mortis in dead pheasants. Pathologico-anatomical dissection of the pheasants obtained under conditions of acute intoxication did not rev eal any changes on the organs of both experimental and control pheasan ts which would be immediately connected with the effect of the adminis tered substance. Hyperaemia was recorded by histologico-pathological i nvestigation of the liver and kidneys. No changes on the brain and int estine wall were recorded.