PFCRK-1, A DEVELOPMENTALLY-REGULATED CDC2-RELATED PROTEIN-KINASE OF PLASMODIUM-FALCIPARUM

Authors
DOERIG C DOERIG C HORROCKS P COYLE J CARLTON J SULTAN A ARNOT D CARTER R
Citation
C. Doerig et al., PFCRK-1, A DEVELOPMENTALLY-REGULATED CDC2-RELATED PROTEIN-KINASE OF PLASMODIUM-FALCIPARUM, Molecular and biochemical parasitology, 70(1-2), 1995, pp. 167-174
Citations number
42
Categorie Soggetti
Parasitiology,Biology
Journal title
Molecular and biochemical parasitology → ACNP
ISSN journal
01666851
Volume
70
Issue
1-2
Year of publication
1995
Pages
167 - 174
Database
ISI
SICI code
0166-6851(1995)70:1-2<167:PADCPO>2.0.ZU;2-T
Abstract
A gene encoding a novel cdc2-related protein kinase has been identifie d in Plasmodium falciparum, using degenerate oligonucleotides designed to hybridise to regions that are conserved in members of the cdc2 gen e family. This gene, called Pfcrk-1, is located on chromosome 4. It is most closely related to the p58(GTA) gene family, members of which ar e negative regulators of cell growth in vertebrates. Pfcrk-1 is develo pmentally regulated, as indicated by stage-specific accumulation of mR NA in gametocytes.