A CASE OF DIABETIC AMYOTROPHY ASSOCIATED WITH 3243 MITOCHONDRIAL TRNA(LEU UUR) MUTATION AND SUCCESSFUL THERAPY WITH COENZYME-Q10

We report the case of 71-year-old male who was once diagnosed as havin g diabetic amyotrophy, because of pronounced wasting in proximal muscl es, massive weight loss, and development of paresthesia in his legs. A fterwards, ragged red fibers and mitochondrial tRNA mutation at positi on 3243 were documented in muscle biopsy. He had diabetes mellitus ass ociated with 3243 mitochondrial DNA mutation, suggesting that clinical ly, diabetic amyotrophy may be overlapped with mitochondria-related di sease entities in some parts. Coenzyme Q10 administration was effectiv e in relieving the symptoms in his legs, fatigue, and residual urine i n his bladder. These were confirmed with the improvement in neurologic al parameters. In conclusion, this case gives important help in unders tanding myopathy in diabetes. It would be important to check on the 32 43 mitochondrial tRNA mutation in patients with diabetic amyotrophy an d/or diabetic neuropathic symptoms.