A number of studies have reported that psychological factors play a si
gnificant role in TMD. Several studies have identified subgroups of pa
tients based on their responses to psychological assessments; however,
none of these studies have reported on the clinical utility of classi
fications of TMD patients on these various measures. In this study, th
e differential response of 133 TMD patients classified within 3 psycho
social-behaviorally based subgroups to a conservative, standardized tr
eatment was examined. The treatment consisted of the combination of an
intra-oral appliance, biofeedback, and stress management. Follow-up a
ssessments were conducted 6 months after treatment termination. The re
sults demonstrated that overall as a group patients significantly impr
oved and maintained improvements on physical, psychosocial, and behavi
oral measures (P < 0.0001). Comparisons across patient subgroups, howe
ver, revealed differential patterns of improvement on the outcome meas
ures. Most notably, reliable change indices demonstrated that the pati
ents classified into a subgroup characterized by the greatest degree o
f psychological distress (Dysfunctional) demonstrated significantly gr
eater improvements on measures of pain intensity (P < 0.001), perceive
d impact of TMD symptoms on their lives (P < 0.001), depression (P < 0
.01), and negative thoughts (P < 0.001), compared with groups characte
rized by greater interpersonal problems (Interpersonally Distressed) a
nd those patients who appeared to be the least disabled by TMD (Adapti
ve Copers). These data provide support for the clinical utility of a p
sychosocial-behavioral classification system and suggest that in futur
e research individualizing treatments and outcome measures based on pa
tient characteristics may improve treatment efficacy and outcome evalu
ation.