CADHERIN-DEPENDENT CELL-AGGREGATION IS AFFECTED BY DECAPEPTIDE DERIVED FROM RAT EXTRACELLULAR-SUPEROXIDE DISMUTASE

Authors
WILLEMS J BRUYNEEL E NOE V SLEGERS H ZWIJSEN A MEGE RM MAREEL M
Citation
J. Willems et al., CADHERIN-DEPENDENT CELL-AGGREGATION IS AFFECTED BY DECAPEPTIDE DERIVED FROM RAT EXTRACELLULAR-SUPEROXIDE DISMUTASE, FEBS letters, 363(3), 1995, pp. 289-292
Citations number
17
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
363
Issue
3
Year of publication
1995
Pages
289 - 292
Database
ISI
SICI code
0014-5793(1995)363:3<289:CCIABD>2.0.ZU;2-N
Abstract
A synthetic HAV-containing decapeptide homologous to the amino acid se quence (44)R-Q(53) in rat extracellular superoxide dismutase B affects cadherin-dependent cell aggregation. Cell hues, some of them transfec ted, expressing different types of cadherins were tested using in vitr o cell aggregation and cell dissociation assays, A concentration-depen dent inhibition of aggregation by the EC-SOD-derived HAV-containing pe ptide was detected only in N-cadherin expressing cells, These results suggest the localisation and possible protective role of EC-SOD B for cells expressing N-cadherin.