Objective: The authors examined individual differences in stress react
ivity as well as whether features of the illness itself or psychologic
al characteristics differentiate between patients with bipolar disorde
r who are highly stress reactive and those who are nor. Method: They a
ssessed stressors and bipolar episodes in 58 patients with bipolar dis
order followed for at least 1 year. Results: Not only did stress level
predict relapse, so did personality variables such as introversion an
d obsessionality and their interaction with stress. Number of previous
episodes of bipolar illness, however, did not affect stress response.
Conclusions: These results are not consistent with the view that epis
odes of bipolar disorder become increasingly independent of stressors
after initial episodes. However, psychological traits may affect react
ivity to stressors.