In a semantic priming paradigm, the effects of different levels of pro
cessing on the N400 were assessed by changing the task demands. In the
lexical decision task, subjects had to discriminate between words and
nonwords, and in the physical task, subjects had to discriminate betw
een uppercase and lowercase letters. The proportion of related versus
unrelated word pairs differed between conditions. A lexicality test on
reaction times demonstrated that the physical task was performed nonl
exically. Moreover, a semantic priming reaction time effect was obtain
ed only in the lexical decision task. The level of processing clearly
affected the event-related potentials. An N400 priming effect was only
observed in the lexical decision task. In contrast, in the physical t
ask a P300 effect was observed for either related or unrelated targets
, depending on their frequency of occurrence. Taken together, the resu
lts indicate that an N400 priming effect is only evoked when the task
performance induces the semantic aspects of words to become part of an
episodic trace of the stimulus event.