S. Nesci et al., AN UNUSUAL DRB1-ASTERISK-1503 HAPLOTYPE WITHOUT A DETECTABLE DRB5 LOCUS IN A BLACK-AFRICAN FAMILY, Tissue antigens, 49(1), 1997, pp. 53-55
A DRB11503 allele not associated with DRB5 locus has been detected in
an African family during routine HLA typing for bone marrow transplan
tation. PCR/SSOP analysis showed the DR2-associated alleles in all the
family members but the DRB5 locus appeared to be absent in the patien
t and his brother. The samples were then analyzed for the presence of
DRB6 pseudogenes and we found that the unusual haplotype was associate
d with DRB60101 allele. This finding strengthen the hypothesis of a r
ecombination hot spot between DRB1 and DRB6 genes.