AN UNUSUAL DRB1-ASTERISK-1503 HAPLOTYPE WITHOUT A DETECTABLE DRB5 LOCUS IN A BLACK-AFRICAN FAMILY

Authors
NESCI S TALEVI N ANDREANI M MANNA M ILIESCU A LUCARELLI G
Citation
S. Nesci et al., AN UNUSUAL DRB1-ASTERISK-1503 HAPLOTYPE WITHOUT A DETECTABLE DRB5 LOCUS IN A BLACK-AFRICAN FAMILY, Tissue antigens, 49(1), 1997, pp. 53-55
Citations number
10
Categorie Soggetti
Immunology,"Cell Biology
Journal title
Tissue antigens → ACNP
ISSN journal
00012815
Volume
49
Issue
1
Year of publication
1997
Pages
53 - 55
Database
ISI
SICI code
0001-2815(1997)49:1<53:AUDHWA>2.0.ZU;2-T
Abstract
A DRB11503 allele not associated with DRB5 locus has been detected in an African family during routine HLA typing for bone marrow transplan tation. PCR/SSOP analysis showed the DR2-associated alleles in all the family members but the DRB5 locus appeared to be absent in the patien t and his brother. The samples were then analyzed for the presence of DRB6 pseudogenes and we found that the unusual haplotype was associate d with DRB60101 allele. This finding strengthen the hypothesis of a r ecombination hot spot between DRB1 and DRB6 genes.