LONG-LASTING EFFECTS OF AN ACUTE STRESS ON THE NEUROCHEMISTRY AND FUNCTION OF 5-HYDROXYTRYPTAMINERGIC NEURONS IN THE MOUSE-BRAIN

Citation
S. Davis et al., LONG-LASTING EFFECTS OF AN ACUTE STRESS ON THE NEUROCHEMISTRY AND FUNCTION OF 5-HYDROXYTRYPTAMINERGIC NEURONS IN THE MOUSE-BRAIN, Psychopharmacology, 118(3), 1995, pp. 267-272
Citations number
36
Categorie Soggetti
Neurosciences,Psychiatry,"Pharmacology & Pharmacy",Neurosciences,Psychiatry,"Pharmacology & Pharmacy
Journal title
Volume
118
Issue
3
Year of publication
1995
Pages
267 - 272
Database
ISI
SICI code
Abstract
The present experiments investigated the effects of a novel stress cha llenge (6-min swim test) on behaviour (immobility) and the neurochemis try of cortical 5-hydroxytryptaminergic neurones in CD1 mice. The infl uence of previous experience of stress (once-daily saline injection) o r administration of the noradrenaline and 5-hydroxytryptamine (5-HT) u ptake blocker, sibutramine hydrochloride, on any changes was also eval uated. 5-HT2A receptor binding was unchanged 24 h after the last injec tion of either saline or sibutramine alone but immobility in the swim test was reduced to the same extent by these pretreatments. Seven days , but not 3 h, after the swim test, the density of 5-HT2A receptors an d the frequency of 5-HT2A receptor-mediated head-twitches were increas ed significantly. These increases were prevented by saline injection, but sibutramine prevented the increase in head-twitches only. Sibutram ine, but not saline, reduced 5-HT synthesis and 5-HT2A receptor-mediat ed head-twitches 3 h after the swim and increased synthesis at 7 days. The results indicate that a brief stress can have long-term effects o n central 5-hydroxytryptaminergic neurones. Previous experience of str ess or sibutramine has marked, but dissimilar, effects on these change s. These findings might be relevant to long-lasting CNS disorders prov oked, or aggravated, by stress.