INHIBITION OF MAO-B PROTECTS AGAINST MDMA-INDUCED NEUROTOXICITY IN THE STRIATUM

Authors
SPRAGUE JE NICHOLS DE
Citation
Je. Sprague et De. Nichols, INHIBITION OF MAO-B PROTECTS AGAINST MDMA-INDUCED NEUROTOXICITY IN THE STRIATUM, Psychopharmacology, 118(3), 1995, pp. 357-359
Citations number
13
Categorie Soggetti
Neurosciences,Psychiatry,"Pharmacology & Pharmacy",Neurosciences,Psychiatry,"Pharmacology & Pharmacy
Journal title
Psychopharmacology → ACNP
Volume
118
Issue
3
Year of publication
1995
Pages
357 - 359
Database
ISI
SICI code
Abstract
The effects of the MAO-B inhibitors, L-deprenyl and MDL-72974 on MDMA- induced serotonergic neurotoxicity in rats were examined. MDMA alone p roduced a significant decrease in the number of 5-HT uptake sites, mea sured as a decrease in the B-max for binding of [H-3]paroxetine, and i n 5-HT and 5-HIAA levels in the striatum. L-Deprenyl and MDL-72974 att enuated this MDMA-induced decrease in serotonergic markers. The data s uggest a key role for MAO-B in the expression of the neurotoxicity pro duced by MDMA in the striatum.