CULTURED-CELL PATTERNING FOR BIO-ELECTRONICS

Adhesion and proliferation of cells on ion-implanted segmented polyure thane (SPU) surfaces was investigated. Cell adhesion and proliferation on non-implanted SPU surfaces was not observed. However, complete cel l adhesion and proliferation was observed on ion-implanted SPU surface s. Also, selective cell adhesion on the patterned organic substrates w as controlled by ion implantation. A specific interaction between cell s and micro-periodic structures produced by ion implantation is demost rated. It was concluded that the improvement of cell adhesion and prol iferation was due to carbonized SPU surface. The obtained pattern of c ultured cells may be useful for formation of neural networks and bio-e lectronics.