K. Atkinson et al., LENOGRASTIM ADMINISTRATION TO HLA-IDENTICAL DONOR-RECIPIENT PAIRS TO ACCELERATE MARROW RECOVERY POSTTRANSPLANT, Bone marrow transplantation, 19(1), 1997, pp. 15-21
In an attempt to accelerate marrow recovery after HLA-identical siblin
g bone marrow transplantation, the donors of 12 patients with haematol
ogical malignancy were given recombinant human granulocyte colony-stim
ulating factor (rHuG-CSF; lenograstim; Granocyte) 5 mu g/kg/day for se
ven doses prior to marrow harvest. All 12 recipients also received len
ograstim 5 mu g/kg/day from the day of transplant until their neutroph
il count was 1.0 x 10(9)/l, In addition to lenograstim post-transplant
and lenograstim-stimulated donor bone marrow the first six recipients
also received donor peripheral blood stem cells that had been enriche
d for CD34(+) stem/progenitor cells and T cell depleted on an immune a
bsorption column (cohort 1), The second six patients (cohort 2) receiv
ed lenograstim post-transplant and lenograstim-stimulated donor marrow
only. All 12 patients showed a marked elevation of their circulating
white blood cell count (predominantly neutrophils) on day 1 post-trans
plant. Compared to carefully matched historical control patients the r
ate of neutrophil engraftment was significantly accelerated in both pa
tient cohorts and platelet engraftment was accelerated in cohort 2.