CLINICAL-FEATURES AND SUCCESSFUL RECOVERY FROM DISSEMINATED NOCARDIOSIS AFTER BMT

Nocardiosis has rarely been described after BMT, When the doses of imm unosuppressive therapy were tapered, a 46-year-old BMT recipient devel oped chronic graft-versus-host disease (GVHD) and immunosuppressive dr ugs were increased, Sixteen days later the patient developed nocardios is diagnosed by lung biopsy, Trimethoprim/sulfamethoxazole (TMP/SMZ) w as initiated but the doses were reduced because of rising creatinine l evels, Skin and cerebral dissemination of nocardiosis was observed and TMP/SMZ doses were increased, After 4 months, the brain lesion was un altered despite resolution of pulmonary lesions, Clinical improvement was observed after drainage of the brain abscess.