SUCCESSFUL HEMATOPOIETIC RECONSTITUTION BY TRANSPLANTATION OF UMBILICAL-CORD BLOOD-CELLS IN A TRANSFUSION-DEPENDENT CHILD WITH DIAMOND-BLACKFAN ANEMIA

Authors
BONNO M AZUMA E NAKANO T HIGASHIKAWA M KAWASKI H NISHIHARA H OBATA M UMEMOTO M SAKATOKU H KOMADA Y ITO M NAGAI M SAKURAI M
Citation
M. Bonno et al., SUCCESSFUL HEMATOPOIETIC RECONSTITUTION BY TRANSPLANTATION OF UMBILICAL-CORD BLOOD-CELLS IN A TRANSFUSION-DEPENDENT CHILD WITH DIAMOND-BLACKFAN ANEMIA, Bone marrow transplantation, 19(1), 1997, pp. 83-85
Citations number
8
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
19
Issue
1
Year of publication
1997
Pages
83 - 85
Database
ISI
SICI code
0268-3369(1997)19:1<83:SHRBTO>2.0.ZU;2-G
Abstract
A 4-year-old boy with Diamond-Blackfan anemia and a history of multipl e transfusions underwent umbilical cord blood transplantation from his HLA-identical female sibling born by vaginal delivery at 38 weeks, Th e patient was prepared,vith busulfan, cyclophosphamide and antilymphoc yte globulin, Methotrexate and cyclosporin A were given for the prophy laxis of GVHD, Regimen-related toxicity was not observed and successfu l engraftment occurred, including the erythroid series. No evidence of acute or chronic GVHD has been observed for 14 months after transplan tation. This is the first case of successful umbilical cord blood tran splantation to a patient with Diamond-Blackfan anemia.