An in vitro test is described that simulates the in vivo fate of a den
ture adhesive, namely destruction, dilution, and dissolution of the ad
hesive, by repeated measurement of tensile bond strength for the adhes
ive in isotonic saline over time. The bond strengths were measured und
er two different settings of the testing machine. The main composition
s of three denture adhesive pastes, Fittydent, Fixodent, and Super Pol
l-Grip and one powder adhesive, Super Wernet's, were determined by inf
rared spectroscopy. The tensile bond strengths of these adhesives and
those of pure tragacanth gum were subjected to a three-way analysis of
variance. The Fittydent and Super Poll-Grip adhesives exhibited the b
est results over time. The most appropriate of the described methods f
or testing denture adhesives seem useful; however, when seen in relati
on to the results of a published clinical study where the patients wer
e asked to evaluate the retention and the duration of some of these ad
hesives, there are indications that the clinical validity of the metho
d might be improved if paste adhesives are tested at temperatures abov
e 35 degrees C.