SIMIAN IMMUNODEFICIENCY VIRUS (SIV)-SPECIFIC CTL IN CEREBROSPINAL-FLUID AND BRAINS OF SIV-INFECTED RHESUS MACAQUES

Simian immunodeficiency virus (SIV)-specific CD8(+) CTL were isolated from blood, cerebrospinal fluid, and brains of rhesus macaques infecte d i.v. with SIV. CTL were found as early as 1 wk postinfection and the ir appearance correlated with a decrease of viral Ag (p27) found in th e blood. CTL isolated from cerebrospinal fluid and/or brain often reco gnized different viral proteins than CTL isolated from blood, suggesti ng either a unique migratory pattern to the central nervous system or a difference in activation/retention of lymphocytes in these compartme nts.