INTERACTION OF TAXOL AND OTHER ANTICANCER DRUGS WITH ALPHA-CYCLODEXTRIN

The interaction between 23 anticancer drugs and alpha-cyclodextrin (al pha-CD) was studied by reversed-phase charge transrer thin-layer chrom atography and the relative strength of interaction was calculated. As alpha-CD has smaller cavity than beta- and tau-CD it interacted only w ith 10 anticancer drugs proving the relatively poor complex forming ca pacity of alpha-CD. The hydrophobicity of host-guest inclusion complex was always different from that of the uncomplexed drug suggesting tha t the complex formation may influence the uptake, absorption, half-lif e etc. of the original drug. the inclusion forming capacity of drugs d iffered considerably according to their chemical structure. The intens ity of interaction significantly depended on the hydrophobicity of the guest molecule proving the preponderant role of hydrophobic interacti ons in inclusion complex formation.