Ap. Miller et al., 3 GENES THAT ESCAPE X-CHROMOSOME INACTIVATION ARE CLUSTERED WITH A 6-MB YAC-CONTIG AND STS MAP IN XP11.21-P11.22, Human molecular genetics, 4(4), 1995, pp. 731-739
In order to study the distribution of genes that escape X chromosome i
nactivation, a high density yeast artificial chromosome (YAC) contig a
nd STS map spanning approximately 6 Mb has been constructed in Xp11.21
-p11.22. The contig contains 113 YACs mapped with 53 markers, includin
g 10 genes. Four genes have been assayed for their expression status o
n both the active and inactive human X chromosomes, and these data hav
e been combined with previous results on two other genes in the contig
. Three of these genes escape X inactivation and have been localized t
o a single YAC clone of similar to 1075 kb. The other three genes are
subject to inactivation, with two of them lying among the genes that e
scape inactivation. These results suggest that there are both regional
control signals as well as gene-specific elements that determine the
X inactivation status of genes on the proximal short arm of the human
X chromosome.