INHIBITORY ACTIVITY OF ANTI-BETA(2)-GLYCOPROTEIN-I ANTIBODY ON FACTORVA DEGRADATION BY ACTIVATED-PROTEIN-C AND ITS COFACTOR PROTEIN-S

Authors
MATSUDA J GOHCHI K KAWASUGI K GOTOH M SAITOH N TSUKAMOTO M
Citation
J. Matsuda et al., INHIBITORY ACTIVITY OF ANTI-BETA(2)-GLYCOPROTEIN-I ANTIBODY ON FACTORVA DEGRADATION BY ACTIVATED-PROTEIN-C AND ITS COFACTOR PROTEIN-S, American journal of hematology, 49(1), 1995, pp. 89-91
Citations number
9
Categorie Soggetti
Hematology
Journal title
American journal of hematology → ACNP
ISSN journal
03618609
Volume
49
Issue
1
Year of publication
1995
Pages
89 - 91
Database
ISI
SICI code
0361-8609(1995)49:1<89:IAOAAO>2.0.ZU;2-Q
Abstract
We investigated the influence of anti-beta(2)-glycoprotein I (aGPI), w hich recently has come to be regarded as anti-cardiolipin antibody (aC L) itself, on factor Va (FVa) degradation by activated protein C/prote in S system, We found that aGPI had an inhibitory effect on FVa degrad ation with beta(2)-glycoprotein I-dependency, thus suggesting aGPI/aCL is a highly possible factor as the pathogenesis of thrombosis observe d in aGPI/aCL-positive patients. (C) 1995 Wiley-Liss, Inc.