Rationale and Objectives. The authors investigated how training and ex
perience affect the performance of observers searching mammograms for
breast masses. Methods. Eye positions of mammographers, mammography te
chnologists, mammography residents, and laypersons were compared to sc
an paths generated by a simulated scanner as each searched nine two-vi
ew digital mammogram pairs for breast masses. Results. Analysis of tim
e-to-hit data revealed that mammographers and mammography technologist
s with the most extensive training and experience had the fastest sear
ch times in the detection and confirmation of a breast mass on two vie
ws. Scanning patterns of less-experienced mammography residents were l
ess efficient due to wider dispersion of visual attention between pote
ntial breast masses and perturbations in breast parenchyma. Because la
ypersons lacked both training and experience in mammography, bright bl
obs in the breast image were considered to be intuitively valid target
candidates and these features distracted the search by capturing visu
al attention. Conclusion. Experience reading normal and abnormal mammo
grams plays a critical role in training radiologists. Experience combi
ned with training provides the basis for generating efficient visual s
earch strategies and developing distinctive conceptual criteria for pe
rceptual differentiation and interpretation of true breast masses from
image artifacts and structured noise that mimics breast abnormalities
.