THE SOLUBLE INTERLEUKIN-2 RECEPTOR, PERIPHERAL-BLOOD, AND RETICULOCYTE FRACTIONS IN ACUTE-PANCREATITIS

Conclusion. In acute pancreatitis (AP), the peripheral blood analysis, including reticulocytes (RC) and RC fractions, and its relationship t o the changes of the levels of the soluble interleukin 2 receptor (sIL -2R) can provide useful information about the involvement of the immun oinflammatory system in AP and can indicate the severity of the diseas e. Background. In the disease clinical assessment, we correlated the s IL-2R serum levels to the peripheral blood components (including RC an d RC fractions) to serum albumin and C-reactive protein (CRP) during A P. Methods. In 21 patients with AP, sIL-2R, the total and differential white blood cell (WBC) counts, red blood cell(RBC) counts, RC, RC fra ctions, hemoglobin (Hb), hematocrit (Ht), platelets (PLT), albumin, an d CRP were evaluated from the onset to the sixth day of illness. Resul ts. sIL-2R increased in all the patients. The increase was directly re lated to eosinophils, monocytes, and to middle-aged (MFR) RC, and inve rsely related to neutrophils and the old (LFR) RC. MFR-RC were directl y related to the total WBC count, eosinophils, and basophils, and inve rsely related to Hb and albumin. LFR-RC behaved in the opposite manner . CRP increased in 16 patients; this rise was directly related to WBC, RC, and MFR-RC, and inversely related to Hb, LFR-RC, and albumin. sIL -2R and CRP values were not statistically interrelated, but when the C RP levels were higher, the increase in sIL-2R was greater and more sus tained.