MOLECULAR-STRUCTURE AND ABSOLUTE-CONFIGURATION OF TITHONIN, A HELIANGOLIDE FROM TITHONIA-ROTUNDIFOLIA

Authors
RODRIGUEZ JG PERALES A RODRIGUEZUBIS JC VAZQUEZ P BORGES J
Citation
Jg. Rodriguez et al., MOLECULAR-STRUCTURE AND ABSOLUTE-CONFIGURATION OF TITHONIN, A HELIANGOLIDE FROM TITHONIA-ROTUNDIFOLIA, Journal of natural products, 58(3), 1995, pp. 446-449
Citations number
9
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
58
Issue
3
Year of publication
1995
Pages
446 - 449
Database
ISI
SICI code
0163-3864(1995)58:3<446:MAAOTA>2.0.ZU;2-B
Abstract
The molecular structure and absolute configuration of tithonin [1], a heliangolide isolated from Tithonia rotundifolia, have been determined by X-ray diffraction analysis. Correlations between the position and stereochemistry of the gamma-lactone ring fusion to the ten-membered r ing and the sign of the Cotton effect of the n-pi transition of the C =C-C=O chromophore of 1 have been analyzed.