P. Airo et al., MONOCLONAL EXPANSION OF LARGE GRANULAR LYMPHOCYTES WITH A CD4(-CD8DIM(+())-) PHENOTYPE ASSOCIATED WITH HAIRY-CELL LEUKEMIA/, Haematologica, 80(2), 1995, pp. 146-149
Peripheral blood lymphoid cell expansions with an unusual CD3(+), CD4(
+), CD8dim(+/-), CD11b(+), CD57(+) immunophenotype have recently been
reported. They frequently have the morphology of large granular lympho
cytes (LGL) and can be either monoclonal or polyclonal. Their signific
ance is still unclear and no association with hematological neoplasms
has been described. We report the case of a patient with a monoclonal
expansion of LGL associated with a B-cell-derived hairy cell leukemia.
The two lymphoid clones were not physically associated since T-LGL we
re found in the peripheral blood and hairy cells were detected in the
bone marrow and kidney.