MONOCLONAL EXPANSION OF LARGE GRANULAR LYMPHOCYTES WITH A CD4(-CD8DIM(+())-) PHENOTYPE ASSOCIATED WITH HAIRY-CELL LEUKEMIA/

Citation
P. Airo et al., MONOCLONAL EXPANSION OF LARGE GRANULAR LYMPHOCYTES WITH A CD4(-CD8DIM(+())-) PHENOTYPE ASSOCIATED WITH HAIRY-CELL LEUKEMIA/, Haematologica, 80(2), 1995, pp. 146-149
Citations number
10
Categorie Soggetti
Hematology
Journal title
ISSN journal
03906078
Volume
80
Issue
2
Year of publication
1995
Pages
146 - 149
Database
ISI
SICI code
0390-6078(1995)80:2<146:MEOLGL>2.0.ZU;2-6
Abstract
Peripheral blood lymphoid cell expansions with an unusual CD3(+), CD4( +), CD8dim(+/-), CD11b(+), CD57(+) immunophenotype have recently been reported. They frequently have the morphology of large granular lympho cytes (LGL) and can be either monoclonal or polyclonal. Their signific ance is still unclear and no association with hematological neoplasms has been described. We report the case of a patient with a monoclonal expansion of LGL associated with a B-cell-derived hairy cell leukemia. The two lymphoid clones were not physically associated since T-LGL we re found in the peripheral blood and hairy cells were detected in the bone marrow and kidney.