ESTROGEN-DEPENDENT LDH-Y, A NEW LDH ISOZYME AND FERTILITY FACTOR IN MICE UTERUS DURING EARLY-PREGNANCY

In estrogen treated ovariectomized and pregnant mice on the first day after mating a sixth LDH isozyme appeared at Relative mobility (Rm) 0. 08 to 0.15 and for convenience this isozyme is provisionally designate d as LDH-Y. The appearance of a sixth LDH isozyme (LDH-Y) in mice uter us after ovariectomy and estrogen treatment favours the idea that this isozyme is estrogen dependent. Presence of this LDH-Y in mice uterus during preimplantation and finally its sudden disappearance during imp lantation and post implantation periods further suggest that LDH-Y is estrogen dependent and responsible for restoring fertility in mice.