IMPROVED SUBJECTIVE RESPONSES TO ORCHIECTOMY PLUS NILUTAMIDE (ANANDRON) IN COMPARISON TO ORCHIECTOMY PLUS PLACEBO IN METASTATIC PROSTATE-CANCER

Patients with advanced prostate cancer have a beneficial effect from m aximal androgen blockade in terms of the subjective and objective dela y of progression and median duration of survival, although side effect s do occur more often in the combination treatment than in testicular suppression alone. Significant improvement or delayed deterioration in subjective parameters such as metastatic pain, performance status and urinary disorders strongly suggest (in the absence of validated quest ionnaires of quality of life at the time of this study) that orchiecto my plus nilutamide improves the quality of life as assessed by the sub jective delay of progression, according to NPCP criteria, to an extent which outweighs the majority of adverse events.