CLINICAL HETEROGENEITY OF INSULIN-DEPENDENT DIABETES-MELLITUS IN KOREA

This study was undertaken to find out how many current Korean patients with insulin dependent diabetes mellitus (IDDM) had a previous histor y of non-insulin requiring phase, Fasting serum C-peptide levels were measured in the 2300 diabetic patients during the visit to the Asan Me dical Center, Seoul, Korea. Fifty-nine patients showed fasting serum C -peptide levels below 0.13 nmol/l. These 59 patients were classified f urther into two groups according to their history of insulin requireme nt: group A who required insulin within 1 year after diagnosis or pres ented initially as diabetic ketoacidosis and group B who had non-insul in requiring phase at least for 1 year (median: 5 years; range: 1-23 y ears). Twenty-six patients (44%) were classified into group A and 27 p atients (46%) into group B. Median age of onset was 26 years (range: 1 0-50 years) and 45 years (range: 23-73 years) in groups A and B, respe ctively (P < 0.001). While the two groups had similar values in the cu rrent and maximum body mass indices, sex ratio and the prevalence of i slet cell antibodies, 58% of the group A and 7% of the group B patient s had histories of diabetic ketoacidosis. These results suggest a clin ical heterogeneity in patients with IDDM in Korea.