RODENT P53 SUPPRESSES THE TRANSFORMING ACTIVITY OF THE ACTIVATED NEU ONCOGENE BY MODULATING THE BASAL PROMOTER ACTIVITY OF NEU

Authors
MATIN A XIE YM KAO MC HUNG MC
Citation
A. Matin et al., RODENT P53 SUPPRESSES THE TRANSFORMING ACTIVITY OF THE ACTIVATED NEU ONCOGENE BY MODULATING THE BASAL PROMOTER ACTIVITY OF NEU, International journal of oncology, 6(5), 1995, pp. 1087-1092
Citations number
50
Categorie Soggetti
Oncology
Journal title
International journal of oncology → ACNP
ISSN journal
10196439
Volume
6
Issue
5
Year of publication
1995
Pages
1087 - 1092
Database
ISI
SICI code
1019-6439(1995)6:5<1087:RPSTTA>2.0.ZU;2-4
Abstract
The rat neu oncogene encodes a dominant transforming oncogene. The mou se wild-type p53 suppresses the transforming activity of the neu oncog ene while different p53 mutants demonstrate varying ability to repress neu-induced transformation. Suppression of neu-transforming activity is due to inhibition of transcription. Deletion analysis of the rat ne u promoter shows that p53 represses the basal promoter activity of neu . Therefore, rodent p53 suppresses the transforming potential of neu b y inhibiting transcription from the basal promoter of neu.