AMINOALCOHOLS .2. PREPARATION OF ENANTIOM ERICALLY PURE PHARMACOLOGICALLY ACTIVE BETA-AMINOALCOHOLS

A synthesis of beta-aminoalcohols is described starting from racemic o r enantiomerically pure alpha-hydroxynitriles which were O-protected u sing enantiomerically pure acetal type protective groups. Reduction wi th lithium aluminium hydride yielded O-protected beta-aminoalcohols. W henever diastereomeric O-protected cyanohydrins could not be separated , the mixture was reduced and the resulting O-protected aminoalcohols were separated. Removal of the protective group using hydrogen chlorid e and methanol yielded enantiomerically pure beta-aminoalcohols or the ir corresponding hydrochlorides.