PROTEIN KINASES .5. PROTEIN-KINASE-C AND LIPID SIGNALING FOR SUSTAINED CELLULAR-RESPONSES

Since the second messenger role was proposed for the products of inosi tol phospholipid hydrolysis, considerable progress has been made in ou r understanding of the biochemical mechanism of the intracellular sign aling network. It is now becoming evident that stimulation of a cell s urface receptor initiates a degradation cascade of various membrane li pid constituents. Many of their metabolites have potentials to induce, intensify, and prolong the activation of protein kinase C that is nee ded for sustained cellular responses.