THE EFFECTS OF INTRATHECALLY ADMINISTERED BACLOFEN ON FUNCTION IN PATIENTS WITH SPASTICITY

The purpose of this article is to review the literature on the effects of intrathecally administered baclofen on impairment in spasticity an d muscle activation patterns, on functional limitations in mobility an d self-care, and on disability in daily life roles. We found plentiful evidence of improvement in spasticity, spasms, and bladder function a nd same reports of improved pattens of muscle activation and kinematic s of single-joint movement. Improved ability to accomplish transfers, self-care, and locomotion is less consistently studied but has also be en reported an about 60% to 70% of Patients. Evidence of improved qual ity of life is primarily anecdotal but may be found in 10% to 30% of p atients. We conclude that research protocols should be developed to cl arify effects on control of voluntary movement, functional limitations , and quality of life.