ASSOCIATION OF STRUCTURAL VARIANTS OF THE GENE OF APOLIPOPROTEIN-B WITH CORONARY HEART-DISEASE AND SERUM-LIPID LEVEL

Xba I and EcoR I polymorphism of the apolipoprotein B (APOB) gene was studied by PCR. A significant increase in the frequency of allele X(+) and haplotype H(+)E(+) was demonstrated in patients with coronarograp hically documented coronary heart disease (CHID) over that of the gene ral population. Association of allele E(-) with increased levels of se rum triglycerides was found. The results provide evidence about the co ntribution of structural variants of the APOB gene to determining CMD.