CIRCADIAN VARIATIONS OF PLASMINOGEN-ACTIVATOR ACTIVITY, TISSUE-TYPE PLASMINOGEN-ACTIVATOR ANTIGEN, PLASMINOGEN-ACTIVATOR INHIBITION AND PLASMIN INHIBITION IN RAT AORTA, HEART AND BRAIN ARE INFLUENCED BY ENDOTOXIN OR ASPIRIN OR ENDOTOXIN PLUS ASPIRIN

The effect of aspirin or endotoxin or aspirin plus endotoxin on the ci rcadian variations of plasminogen activator activity (PAA), tissue-typ e plasminogen activator (t-PA) antigen level, plasminogen activator in hibition (PAI) and plasmin inhibition (PI) in aorta, heart and brain o f the rat was studied. In aorta the circadian variations of PAA, t-PA antigen and tissue-type PAI (t-PAI) were blunted by endotoxin, while t he circadian variation of PI was reversed; t-PAI variation was blunted by aspirin plus endotoxin, while PI variation was reversed. Various d isturbances of the circadian variations of PAA, t-PA antigen, PAI or P I in heart and brain were also observed. In conclusion, the circadian variations of fibrinolytic parameters in key organs are influenced by aspirin or endotoxin or aspirin plus endotoxin in a varying way or deg ree depending on the treatment, the parameter studied or the organ.