2,6-DIACETYLPYRIDINE BIS(THIOSEMICARBAZONES) ZINC-COMPLEXES - SYNTHESIS, STRUCTURE, AND BIOLOGICAL-ACTIVITY

Citation
Mc. Rodriguezarguelles et al., 2,6-DIACETYLPYRIDINE BIS(THIOSEMICARBAZONES) ZINC-COMPLEXES - SYNTHESIS, STRUCTURE, AND BIOLOGICAL-ACTIVITY, Journal of inorganic biochemistry, 58(3), 1995, pp. 157-175
Citations number
29
Categorie Soggetti
Biology,"Chemistry Inorganic & Nuclear
ISSN journal
01620134
Volume
58
Issue
3
Year of publication
1995
Pages
157 - 175
Database
ISI
SICI code
0162-0134(1995)58:3<157:2BZ-S>2.0.ZU;2-2
Abstract
The reaction of zinc chloride, acetate, or perchlorate with two bis(th iosemicarbazones) of 2,6-diacetylpyridine [H(2)daptsc = 2,6-diacetylpy ridine bis(thiosemicarbazone) and H(2)dapipt = 2,6-diacetylpyridine bi s(hydrazinopyruvoylthiosemicarbazone)] leads to the formation of four novel complexes that have been characterized by spectroscopic studies (NMR, IR) and biological properties. The crystal structures of the two compounds-[Zn(daptsc)](2) . 2DMF (1) and [Zn(H(2)dapipt)(OH2)(2)](ClO 4)(2) . 3H(2)O (2)-also have been determined by x-ray methods from dif fractometer data. Compound (1) is dimeric and the two zinc atoms have a distorted octahedral coordination. The ligand is deprotonated. In co mpound (2), the coordination geometry about zinc is pentagonal-bipyram idal and the ligand is in the neutral form. The molecular structure of (2) consists of cations [Zn(H(2)dapipt)(OH2)(2)](2+), ClO4- disordere d anions, and three water molecules of solvation. Biological studies h ave shown that the ligands and the complexes Zn(daptsc). 1/2EtOH and Z n(H(2)daptsc)Cl-2 have an effect in vitro on cell proliferation and di fferentiation (inhibition); both are concentration dependent. [Zn(dapt sc)](2) . 2DMF (1) shows the effects at lower concentration values wit h respect to other compounds.