CYTOGENETIC AND MOLECULAR STUDIES ON THE NEUROBLASTOMA CELL-LINE NGP - IDENTIFICATION OF A RECIPROCAL T(1-15) INVOLVING THE CONSENSUS REGION 1P36.1

A reciprocal t(1;15)(p36.1-36.3;q25-26) has been identified in an esta blished neuroblastoma cell line (NGP) that earlier studies had shown t o carry, among others, a rearrangement at the Ip subtelomeric region. Though it has not been possible to establish whether this translocatio n was constitutional, it is of interest to note that one of the breakp oints is located within the well-known Ip consensus site of tumor-asso ciated chromosomal rearrangements where, as a result of the reciprocal translocation, the FES oncogene has been transferred from autosome 15 . It is to be expected that the molecular cloning of the Ip and 15q tr anslocation breakpoints may yield crucial data for understanding the a ssociation between specific chromosomal rearrangements and malignant t umor progression. (C) 1995 Wiley-Liss, Inc.